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Journal/Book: J Biomol NMR
Published: 1994
Pages: 631–644
Volume: 4
Issue:
Accession no.: 9
Publisher:
ISBN:

Determination of a complete set of coupling constants in 13C-labeled oligonucleotides.

H. Schwalbe, J. P. Marino, G. C. King, R. Wechselberger, W. Bermel, C. Griesinger
Abstract:
Three experiments are introduced to determine a complete set of coupling constants in RNA oligomers. In the HCCH-E.COSY experiment, the vicinal proton-proton coupling constants can be measured with high accuracy. In the P-FIDS-CT-HSQC experiment, vicinal proton-phosphorus and carbon-phosphorus couplings are measured that depend on the phosphodiester backbone torsion angles beta and epsilon. In the refocussed HMBC experiment, vicinal carbon-proton couplings are measured that depend on the glycosidic torsion angle chi.
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Prof. Dr. Harald Schwalbe
Institut für Organische Chemie und Chemische Biologie
Johann Wolfgang Goethe Universität
Max-von-Laue-Str. 7
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