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Journal/Book: Chem. Commun
Published: 2024
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Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocyclization

B, Lala, R. Chaudhuri, T. Prasanth, I. Burkhart, H. Schwalbe, J. Dash
Abstract:
The G-quartet-like supramolecular assembly present in guanosine hydrogel templates macrocyclization between bis-azide and bis-alkyne fragments. The resulting macrocycle enhances viscoelastic properties, and strengthens the hydrogel network. This approach holds potential for the in situ synthesis of drugs and their simultaneous delivery in a stimuli-responsive manner.
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Prof. Dr. Harald Schwalbe
Institut für Organische Chemie und Chemische Biologie
Johann Wolfgang Goethe Universität
Max-von-Laue-Str. 7
D-60438 Frankfurt am Main
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