Prof. Dr. Harald Schwalbe

  • N160 / 3.OG / Raum Nr. 313
  • +49 (0)69 / 798-29737
  • +49 (0)69 / 798-29515

Research: The research in our group is focussed on the development and application of nuclear magnetic resonance (NMR) spectroscopy to study biomacromolecules. Our focus is to contritube to a molecular understanding of fundamental mechanism of biomacromolecules. We investigate both, soluble proteins and membrane proteins. We investige RNAs and RNA-protein complexes and unusual DNA structures including G-quadruplexes and i-motifs.

Special emphasis is on time-resolved NMR experiments; we have developed methodogies to induce protein, DNA- or RNA-folding either by mixing or by light from compounds that are caged in one (of several) conformations by photolabile protecting groups or natural light-absorbing chromophors. Some of these caged molecules are synthesized in the lab. A different way of inducing biomacromolecular folding is by temperature jump; thus we have developed T-jump probes to do these kind of experiments.

We also investigate proteins structures to contribute to rational drug discovery and support our mechanistic studies by chemical synthesis.

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Prof. Dr. Harald Schwalbe
Institut für Organische Chemie und Chemische Biologie
Johann Wolfgang Goethe Universität
Max-von-Laue-Str. 7
D-60438 Frankfurt am Main
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